Enalapril Maleate (ENALAPRIL MALEATE) Warnings...

Enalapril Maleate (ENALAPRIL MALEATE)

Warnings

Anaphylactoid and Possibly Related Reactions

Patients receiving ACE inhibitors, including enalapril maleate, may be subject to a variety of adverse reactions, some of them serious. These reactions are presumably due to the effect of ACE inhibitors on the metabolism of eicosanoids and polypeptides, including endogenous bradykinin.

Head and Neck Angioedema

Angioedema of the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with enalapril maleate. Prompt discontinuation of enalapril maleate and appropriate therapy and monitoring are necessary until complete resolution of signs and symptoms occurs.

Intestinal Angioedema

Intestinal angioedema, presenting with abdominal pain, has been reported in patients treated with ACE inhibitors. Patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor.

Anaphylactoid Reactions

Anaphylactoid reactions have been reported in patients undergoing desensitizing treatment with hymenoptera venom and in patients undergoing membrane exposure while receiving ACE inhibitors.

Hypotension

Excessive hypotension is rare in uncomplicated hypertensive patients treated with enalapril maleate alone. However, caution should be observed when initiating therapy, especially in patients at risk for excessive hypotension.

Neutropenia/Agranulocytosis

Neutropenia or agranulocytosis has been reported in patients receiving ACE inhibitors. Periodic monitoring of white blood cell counts in certain patients should be considered.

Hepatic Failure

Rare cases of cholestatic jaundice progressing to fulminant hepatic necrosis have been associated with ACE inhibitors. Patients developing jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up.

Fetal Toxicity

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Enalapril maleate should be discontinued as soon as pregnancy is detected.

FAQ

Q: What should I do if I experience symptoms of angioedema while taking enalapril maleate?

A: If you experience symptoms of angioedema such as swelling of the face, lips, tongue, or difficulty breathing, promptly discontinue enalapril maleate and seek immediate medical attention.

Q: Are there any specific patient groups at higher risk for excessive hypotension while taking enalapril maleate?

A: Patients with heart failure, hyponatremia, high-dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion may be at increased risk for excessive hypotension while taking enalapril maleate.

Q: Can enalapril maleate be used during pregnancy?

A: Enalapril maleate should be discontinued as soon as pregnancy is detected due to the risk of fetal toxicity, including reduced fetal renal function and potential adverse effects on the fetus.

Disclaimer: This content is for informational purposes only and should not be considered medical advice. Always consult with a healthcare professional before making any decisions about your health or medication.