Fludrocortisone Acetate (FLUDROCORTISONE ACETATE) ...

Fludrocortisone Acetate (FLUDROCORTISONE ACETATE)

Warnings

Because of its marked effect on sodium retention, the use of fludrocortisone acetate in the treatment of conditions other than those indicated herein is not advised. Corticosteroids may mask some signs of infection, and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used. If an infection occurs during fludrocortisone acetate therapy, it should be promptly controlled by suitable antimicrobial therapy. Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.

Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. However, since fludrocortisone acetate is a potent mineralocorticoid, both the dosage and salt intake should be carefully monitored in order to avoid the development of hypertension, edema, or weight gain. Periodic checking of serum electrolyte levels is advisable during prolonged therapy; dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion.

Patients should not be vaccinated against smallpox while on corticosteroid therapy. Other immunization procedures should not be undertaken in patients who are on corticosteroids, especially on high dose, because of possible hazards of neurological complications and a lack of antibody response.

The use of fludrocortisone acetate in patients with active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen. If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary since reactivation of the disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.

Children who are on immunosuppressant drugs are more susceptible to infections than healthy children. Chickenpox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. In such children, or in adults who have not had these diseases, particular care should be taken to avoid exposure. If exposed, therapy with varicella-zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG), as appropriate, may be indicated. If chickenpox develops, treatment with antiviral agents may be considered.

FAQs

What are the risks of using fludrocortisone acetate?

Fludrocortisone acetate can cause various side effects, including sodium retention, increased blood pressure, salt and water retention, potassium excretion, and potential ocular complications. It is important to monitor electrolyte levels, restrict dietary salt intake, and consider potassium supplementation during prolonged therapy.

Can patients on fludrocortisone acetate receive vaccinations?

Patients on fludrocortisone acetate or other corticosteroids should not be vaccinated against smallpox. Additionally, other immunization procedures should be avoided, especially in high-dose corticosteroid therapy, due to the potential hazards of neurological complications and a lack of antibody response.

Are children on fludrocortisone acetate at higher risk of infections?

Children on immunosuppressant drugs like fludrocortisone acetate are more susceptible to infections, and diseases such as chickenpox and measles can have a more serious or fatal course in these children. Care should be taken to avoid exposure, and in case of exposure, appropriate therapy may be indicated.

Disclaimer: This content is for informational purposes only and should not be considered medical advice. Always consult with a healthcare professional before making any decisions about your health or medication.