What is Lidocaine MPF?
Lidocaine MPF (Methylparaben-Free) is a sterile local anesthetic injection used for local and regional anesthesia during minor surgical, dental, and diagnostic procedures. MPF formulations are preferred when patients have allergies to preservatives like methylparaben.
Why Use Lidocaine MPF?
- Preservative-Free: No methylparaben, reducing allergic reaction risk.
- Clear solution: Suitable for nerve blocks, infiltration, and epidural use.
- Fast Onset: Begins working in 2–5 minutes.
- Reliable: Proven efficacy in clinical anesthesia settings.
Indications & Usage
Lidocaine MPF is widely used in:
- Infiltration anesthesia (e.g., dental or skin procedures)
- Peripheral nerve blocks (e.g., brachial plexus, intercostal nerves)
- Central neural blocks (e.g., lumbar epidurals, caudal blocks)
- Intravenous regional anesthesia (IVRA)
Always administer under the supervision of a trained medical professional.
Dosage Guidelines for Lidocaine MPF
| Procedure Type | Concentration | Typical Volume (mL) | Max Dose (mg) |
| Infiltration | 0.5% or 1% | 1–30 mL | 300 mg |
| Nerve Block | 1% or 2% | 5–40 mL | 300 mg |
| Epidural Block | 1% | 10–20 mL | 300 mg |
| IVRA (Bier’s Block) | 0.5% | 40–50 mL | 300 mg |
Note: Use epinephrine-containing solutions when high volumes are needed. Lower dosages should be used in elderly or medically compromised patients.
Lidocaine MPF vs Lidocaine PF (Preservative-Free)
| Feature | Lidocaine MPF | Lidocaine PF |
| Contains preservatives? | No (MPF = Methylparaben-Free) | No |
| Use for spinal/epidural? | Yes | Yes |
| Safer for allergies? | Yes | Yes |
| Stability for multiple doses | Slightly higher | Lower |
Conclusion: Both are preservative-free, but “MPF” labeling ensures no methylparaben content, making it suitable for sensitive procedures and patients.
What Does MPF Stand For in Lidocaine?
MPF stands for Methylparaben-Free. This means the formulation is free from the preservative methylparaben, which can cause allergic reactions in sensitive individuals.
Side Effects of Lidocaine MPF
Most side effects are dose-related and rare when administered correctly.
Common side effects:
- Tingling or numbness
- Dizziness or lightheadedness
- Nausea
Severe (rare):
- Seizures
- Respiratory depression
- Cardiac arrest
If any adverse reactions occur, seek emergency medical attention immediately.
Warnings and Precautions
- Only trained clinicians should administer Lidocaine MPF.
- Oxygen, resuscitation equipment, and emergency drugs should always be available.
- Avoid intravascular injection—always aspirate before injecting.
Drug Interactions
No major interactions are widely documented, but caution is advised when combining with:
- Antiarrhythmics
- Beta-blockers
- CNS depressants
Always consult a doctor before using with other medications.
FAQs about Lidocaine MPF
Q1. Is Lidocaine MPF safer than regular Lidocaine?
Yes, especially for patients allergic to preservatives.
Q2. Can Lidocaine MPF be used for dental procedures?
Yes, it’s commonly used in dental infiltration and nerve blocks.
Q3. What is Lidocaine MPF 1% and 2%?
These refer to the concentration of Lidocaine. 1% = 10 mg/mL, 2% = 20 mg/mL.
Q4. Who manufactures Lidocaine MPF?
Several companies including Auromedics Pharma LLC, Fresenius Kabi, and Hospira.
Hindi में जानकारी: Lidocaine MPF क्या है?
Lidocaine MPF एक स्थानीय एनेस्थीसिया देने वाली दवा है जो preservatives (जैसे methylparaben) के बिना आती है। इसका इस्तेमाल दर्द रहित इंजेक्शन, दांत निकालने, या छोटे ऑपरेशन में किया जाता है।
अगर आपको दवाओं से एलर्जी है, तो यह सुरक्षित विकल्प हो सकता है। हमेशा डॉक्टर की सलाह से ही उपयोग करें।
Conclusion: Is Lidocaine MPF Right for You?
Lidocaine MPF is a trusted, preservative-free anesthetic for local and regional procedures. Whether you’re a clinician seeking safety or a patient with allergies, MPF formulations offer reliability with fewer risks.
References & Sources
- FDA Drug Database
- Clinical Guidelines in Anesthesia
- Expert review by Dr. Divyensh, General Medicine & Public Health
